03 January 2018
Vol 10, Issue 422

About The Cover

Cover image expansion

ONLINE COVER Cancer Immunotherapy Going Viral. This image shows infection of a tumor by an oncolytic virus (blue), which kills cancer cells, releasing tumor antigens (green). These antigens are taken up by antigen-presenting cells (turquoise) and presented to T cells (purple nucleus). The T cells prepare to kill tumor cells but can be inactivated (gray nucleus) by binding of an immune checkpoint inhibitory receptor (turquoise) to its ligand (pink) on cancer cells. Immune checkpoint blocking antibodies (green) allow T cells to kill the cancer cells. Bourgeois-Daigneault, Samson and their colleagues show how oncolytic virus treatment improves the efficacy of subsequent immune checkpoint blockade against different cancer types. [CREDIT: CHRISTINE KENNEY/C. KENNEY ILLUSTRATION]