Repeat doses of antibody to serum amyloid P component clear amyloid deposits in patients with systemic amyloidosis

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Science Translational Medicine  03 Jan 2018:
Vol. 10, Issue 422, eaan3128
DOI: 10.1126/scitranslmed.aan3128

Article Information

vol. 10 no. 422

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  • Received for publication March 27, 2017
  • Accepted for publication September 26, 2017

Author Information

  1. Duncan B. Richards1,
  2. Louise M. Cookson1,
  3. Sharon V. Barton1,
  4. Lia Liefaard1,
  5. Thirusha Lane2,
  6. David F. Hutt2,
  7. James M. Ritter3,
  8. Marianna Fontana2,
  9. James C. Moon4,
  10. Julian D. Gillmore2,
  11. Ashutosh Wechalekar2,
  12. Philip N. Hawkins2 and
  13. Mark B. Pepys2,5,*
  1. 1GlaxoSmithKline Research and Development, Stevenage, Herts SG1 2NY, UK.
  2. 2National Health Service National Amyloidosis Centre, Centre for Amyloidosis and Acute Phase Proteins, University College London and Royal Free Hospital, London NW3 2PF, UK.
  3. 3Quintiles Drug Research Unit, Guy’s Hospital, London SE1 1YR, UK.
  4. 4University College London Institute of Cardiovascular Science and Barts Heart Centre, St Bartholomew’s Hospital, London EC1A 7BE, UK.
  5. 5Wolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, University College London, London NW3 2PF, UK.
  1. *Corresponding author. Email: m.pepys{at}


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