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Intravenous delivery of oncolytic reovirus to brain tumor patients immunologically primes for subsequent checkpoint blockade

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Science Translational Medicine  03 Jan 2018:
Vol. 10, Issue 422, eaam7577
DOI: 10.1126/scitranslmed.aam7577

Article Information

vol. 10 no. 422

PubMed: 
Print ISSN: 
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History: 
  • Received for publication January 17, 2017
  • Resubmitted September 8, 2017
  • Accepted for publication November 27, 2017

Author Information

  1. Adel Samson1,*,
  2. Karen J. Scott1,,
  3. David Taggart1,,
  4. Emma J. West1,
  5. Erica Wilson1,
  6. Gerard J. Nuovo2,
  7. Simon Thomson3,
  8. Robert Corns3,
  9. Ryan K. Mathew1,
  10. Martin J. Fuller1,
  11. Timothy J. Kottke4,
  12. Jill M. Thompson4,
  13. Elizabeth J. Ilett1,
  14. Julia V. Cockle1,
  15. Philip van Hille3,
  16. Gnanamurthy Sivakumar3,
  17. Euan S. Polson1,
  18. Samantha J. Turnbull1,
  19. Elizabeth S. Appleton1,
  20. Gemma Migneco1,
  21. Ailsa S. Rose1,
  22. Matthew C. Coffey5,
  23. Deborah A. Beirne3,
  24. Fiona J. Collinson6,
  25. Christy Ralph1,
  26. D. Alan Anthoney1,
  27. Christopher J. Twelves1,
  28. Andrew J. Furness7,
  29. Sergio A. Quezada7,
  30. Heiko Wurdak1,
  31. Fiona Errington-Mais1,
  32. Hardev Pandha8,
  33. Kevin J. Harrington9,
  34. Peter J. Selby1,
  35. Richard G. Vile4,
  36. Stephen D. Griffin1,
  37. Lucy F. Stead1,
  38. Susan C. Short1,*, and
  39. Alan A. Melcher9,*,
  1. 1Leeds Institute of Cancer and Pathology, Faculty of Medicine and Health, University of Leeds, St James’s University Hospital, Beckett Street, Leeds, West Yorkshire LS9 7TF, UK.
  2. 2Ohio State University, Comprehensive Cancer Centre, Columbus, OH 43210, USA.
  3. 3Leeds Teaching Hospitals National Health Service Trust, St James’s University Hospital, Beckett Street, Leeds, West Yorkshire LS9 7TF, UK.
  4. 4Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA.
  5. 5Oncolytics Biotech, Calgary, Alberta T2N 1X7, Canada.
  6. 6Leeds Institute of Clinical Trials Research, Faculty of Medicine and Health, University of Leeds, Leeds, West Yorkshire LS2 9JT, UK.
  7. 7University College London, London WC1 6BT, UK.
  8. 8University of Surrey, Guildford GU2 7XH, UK.
  9. 9Institute of Cancer Research, 123 Old Brompton Road, London SW7 3RP, UK.
  1. *Corresponding author. Email: a.samson{at}leeds.ac.uk (A.S.); alan.melcher{at}icr.ac.uk (A.A.M.); s.c.short{at}leeds.ac.uk (S.C.S.)
    • These authors contributed equally to this work.

    • These authors contributed equally to this work.

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    Dec 2017111
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    Feb 20183542221436
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    Jun 20185284260