Research ArticleAutoimmunity

A miRNA181a/NFAT5 axis links impaired T cell tolerance induction with autoimmune type 1 diabetes

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Science Translational Medicine  03 Jan 2018:
Vol. 10, Issue 422, eaag1782
DOI: 10.1126/scitranslmed.aag1782

Article Information

vol. 10 no. 422

PubMed: 
Print ISSN: 
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History: 
  • Received for publication June 27, 2016
  • Resubmitted April 7, 2017
  • Accepted for publication October 27, 2017

Author Information

  1. Isabelle Serr1,2,
  2. Martin G. Scherm1,2,
  3. Adam M. Zahm3,
  4. Jonathan Schug3,
  5. Victoria K. Flynn1,2,
  6. Markus Hippich2,4,
  7. Stefanie Kälin2,5,
  8. Maike Becker1,2,
  9. Peter Achenbach2,4,
  10. Alexei Nikolaev6,
  11. Katharina Gerlach7,
  12. Nicole Liebsch8,
  13. Brigitta Loretz8,
  14. Claus-Michael Lehr8,9,
  15. Benedikt Kirchner10,
  16. Melanie Spornraft10,
  17. Bettina Haase11,
  18. James Segars12,
  19. Christoph Küper13,
  20. Ralf Palmisano14,
  21. Ari Waisman6,
  22. Richard A. Willis15,
  23. Wan-Uk Kim16,17,
  24. Benno Weigmann7,
  25. Klaus H. Kaestner3,
  26. Anette-Gabriele Ziegler2,4 and
  27. Carolin Daniel1,2,*
  1. 1Group Immune Tolerance in Type 1 Diabetes, Institute for Diabetes Research, Helmholtz Diabetes Center at Helmholtz Zentrum München, Munich, Germany.
  2. 2Deutsches Zentrum für Diabetesforschung (DZD), Neuherberg, Germany.
  3. 3Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  4. 4Institute for Diabetes Research, Helmholtz Diabetes Center at Helmholtz Zentrum München, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
  5. 5Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München and Division of Metabolic Diseases, Technische Universität München, Munich, Germany.
  6. 6Institute for Molecular Medicine, Universitätsmedizin der Johannes-Gutenberg-Universität, Mainz, Germany.
  7. 7Department of Medicine 1, University of Erlangen-Nuremberg, Kussmaul Campus for Medical Research, Erlangen, Germany.
  8. 8Department of Drug Delivery, Helmholtz Institute for Pharmaceutical Research Saarland, Hemholtz Centre for Infection Research (HZI), Saarbrücken, Germany.
  9. 9Department of Pharmacy, Saarland University, Saarbrücken, Germany.
  10. 10Physiology Weihenstephan, Technische Universität München, Munich, Germany.
  11. 11Genomics Core Facility, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
  12. 12John Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  13. 13Department of Physiology, University of Munich, Munich, Germany.
  14. 14Optical Imaging Centre Erlangen, University Erlangen, 91052 Erlangen, Germany.
  15. 15Emory Vaccine Center, NIH Tetramer Core Facility, Atlanta, GA 30329, USA.
  16. 16Postech-Catholic Biomedical Engineering Institute, Catholic University of Korea, Seoul, Republic of Korea.
  17. 17Korea University of Science and Technology, Seoul, Republic of Korea.
  1. *Corresponding author. Email: carolin.daniel{at}helmholtz-muenchen.de

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