Contents
21 September 2016
Vol 8, Issue 357
Vol 8, Issue 357
Contents
Focus
- Boosting translational research in the U.K.
Investment in national infrastructure is critical for growth in early-phase translational research and experimental medicine.
Research Articles
- Inhibition of ileal bile acid uptake protects against nonalcoholic fatty liver disease in high-fat diet–fed mice
Inhibition of the ileal bile acid transporter treats multiple features of nonalcoholic steatohepatitis in high-fat diet–fed mice.
- Cytokine-induced memory-like natural killer cells exhibit enhanced responses against myeloid leukemia
Cytokine-induced differentiation of memory-like natural killer cells enhances antileukemia responses.
- IVIG-mediated protection against necrotizing pneumonia caused by MRSA
Human intravenous immunoglobulin contains specific antitoxin antibodies that protect against necrotizing pneumonia caused by MRSA in a rabbit model.
Editors' Choice
- No foie gras with apolipoprotein B inhibitors?
Antisense oligonucleotide-mediated knockdown of apolipoprotein B results in compensatory autophagy to avoid hepatic steatosis.
- Everything you splice can and will be used against you
Leukemia progenitor cells are characterized by unique splice isoform patterns and are selectively sensitized to spliceosome modulation.
- Go with the flow
A molecule that improves microvascular blood flow may reverse sickle cell disease vaso-occlusive pain crisis.
- Alzheimer’s immunotherapy: β-amyloid aggregates come unstuck
The Aβ antibody aducanumab reduces brain Aβ and cognitive decline in patients with early or mild Alzheimer’s disease.
About The Cover
ONLINE COVER Slimming Down the Liver. The image shows fat accumulation in the liver of a mouse fed a high-fat Western-style diet as a model of nonalcoholic fatty liver disease. This condition is becoming increasingly prevalent with the rising incidence of obesity, and treatment options are very limited. In this issue, Rao et al. demonstrate that a drug can decrease fat accumulation in the liver and associated complications in mouse models by blocking the uptake of bile acids in the intestine. [CREDIT: RAO ET AL./SCIENCE TRANSLATIONAL MEDICINE]