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8 February 2012, Vol. 4, #120
Cover Story | Research Article and Focus Targeting Toll-like and Nod-like Receptors Induces Effective Tumor-Specific Immunity

A cancer vaccine of irradiated tumor cells expressing flagellin primes effective NLRC4/NAIP5- and TLR5-dependent antitumor immune responses.


Rapid Publication Fasting Cycles Slow Tumor Growth and Sensitize Different Cancer Cell Types to Chemotherapy

Short-term starvation boosts the effectiveness of chemotherapy against different tumors.

Research Article, Perspective and Podcast Acquired Crizotinib Resistance in ALK-Rearranged Lung Cancers

Lung cancer patients show multiple mechanisms of crizotinib resistance, including new secondary ALK mutations.


Research Article AAV2 Gene Therapy For Treating Congenital Blindness

Repeat administration of gene therapy to the contralateral retina of three congenitally blind patients was safe and resulted in improved vision.

Editors' Choice

Selected literature highlights from our Associate Scientific Advisors. Access to this content is FREE with Registration

Sci TM Podcast - 8 February 2012

Our most recent podcast is a conversation with Jeffrey Engelman about how resistance to targeted chemotherapeutics develops in lung cancer patients (10 minutes, 8 Feb 2012).