Contents
05 December 2018
Vol 10, Issue 470
Vol 10, Issue 470
Research Articles
- A human-derived antibody targets misfolded SOD1 and ameliorates motor symptoms in mouse models of amyotrophic lateral sclerosis
A human-derived antibody that is selective for misfolded SOD1 decreases motor impairments and boosts survival in several rodent models of ALS.
- Wireless, battery-free, flexible, miniaturized dosimeters monitor exposure to solar radiation and to light for phototherapy
Wireless, battery-free, flexible dosimeters measure personalized exposure to electromagnetic radiation outdoors and in clinical environments.
- Noninvasive 11C-rifampin positron emission tomography reveals drug biodistribution in tuberculous meningitis
PET reveals spatially heterogeneous rifampin brain penetration, which decreases rapidly with treatment during tuberculous meningitis.
- Noncoding regions are the main source of targetable tumor-specific antigens
A proteogenomic method identifies potentially actionable tumor-specific antigens and shows that most of them are not coded by classic exons.
Editors' Choice
- A high five for TB screening
Whole-blood transcriptional profiling identifies a five-gene signature for tuberculosis screening among people living with HIV.
- Magnets make target cells more attractive to CRISPR
Local CRISPR-Cas9–mediated genome editing using magnetic nanoparticles complexed with recombinant baculoviral vectors minimizes genotoxicity.
- The virtue of tolerance
A chromatin-inspired nanodrug suppresses undesired immune responses.
Erratum
About The Cover
ONLINE COVER Lean on Me. The photograph depicts an 86-year old farmer under one of the oldest productive olive trees in Sardinia. Analyzing memory B cell repertoires of the healthy elderly enabled Maier et al. to develop human antibodies targeting misfolded forms of superoxide dismutase 1 (SOD1). This enzyme is mutated in an inherited form of the neurodegenerative disease amyotrophic lateral sclerosis (ALS). In animal models of ALS, antibody treatment delayed the onset of motor impairments, extended survival, and reduced the accumulation of SOD1 aggregates and degeneration of neurons. [CREDIT: PHOTOGRAPH BY KARSTEN THORMAEHLEN FROM THE EXHIBITION "PIONEERS OF THE FUTURE" AT THE UNIVERSITY OF ZURICH]