Contents

18 January 2017
Vol 9, Issue 373
  • Research Articles

    • Reporter gene imaging of targeted T cell immunotherapy in recurrent glioma

      PET gene reporter imaging can be used to monitor the trafficking of therapeutic cytotoxic T cells in glioma patients.

    • Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller

      Three new potent neutralizing antibodies neutralize autologous HIV-1 strains and contribute to viral control in an HIV-1 controller.

    • Soft robotic sleeve supports heart function

      A soft robotic sleeve modeled on the structure of the human heart assists cardiovascular function in an ex vivo and in vivo porcine model of heart failure.

    • Follicular CD8 T cells accumulate in HIV infection and can kill infected cells in vitro via bispecific antibodies

      LN inflammation in chronic HIV is associated with accumulation of follicular CD8 T cells that could be redirected to kill infected cells.

    • Tyrosine kinase blocking collagen IV–derived peptide suppresses ocular neovascularization and vascular leakage

      An integrin-binding peptide derived from collagen IV prevents ligand-induced activation of multiple tyrosine kinase receptors and strongly suppresses ocular neovascularization and vascular leakage.

  • Editors Choice

About The Cover

Cover image expansion

ONLINE COVER Artificial Muscles Assist the Heart. This computed tomography image shows a ventricular assist device surrounding an isolated pig heart (Roche et al.). The device, composed of layered pneumatic artificial muscle actuators in a soft polymer material, increased ventricular ejection volume in vitro and cardiac output in vivo during cardiac arrest in pigs. The artificial muscles within the sleeve-like soft robotic device could twist and compress, providing ventricle-specific assistance that mimics the motion of the natural heart. [CREDIT: ROCHE ET AL./SCIENCE TRANSLATIONAL MEDICINE]