Contents
13 March 2019
Vol 11, Issue 483
Vol 11, Issue 483
Perspective
- “Inactive” ingredients in oral medications
Inactive ingredients in oral medications are generally poorly appreciated, and many include materials associated with adverse reactions in patients.
Research Article
- Noninvasive high-resolution electromyometrial imaging of uterine contractions in a translational sheep model
Three-dimensional electromyometrial imaging accurately and noninvasively measures the electrical activation pattern of uterine contractions in sheep.
Report
- A gastric resident drug delivery system for prolonged gram-level dosing of tuberculosis treatment
A retrievable device, compatible with nasogastric tube administration, releases grams of drug over weeks while residing in the stomach.
Research Articles
- Preclinical development of an oral anti-Wolbachia macrolide drug for the treatment of lymphatic filariasis and onchocerciasis
An oral macrolide drug targeting the bacterial endosymbiont, Wolbachia, shows efficacy against filarial nematodes in preclinical animal models.
- ZEB1 suppression sensitizes KRAS mutant cancers to MEK inhibition by an IL17RD-dependent mechanism
Suppression of ZEB1 through miR-200 expression or HDAC inhibition with mocetinostat sensitizes resistant KRAS mutant lung cancers to MEK inhibition.
- An antibody-drug conjugate directed to the ALK receptor demonstrates efficacy in preclinical models of neuroblastoma
ALK is a tractable antibody-drug conjugate target in neuroblastoma.
Editors' Choice
- The lymphatic route of TAU
The brain lymphatic system contributes to TAU clearance in mice.
- The attack of the “seeding” clones
Tumor clone tracking in breast cancer xenografts identifies a small subset of circulating tumor cells as “seeders” associated with metastasis.
- When fat is beneficial
In response to exercise, adipose tissue secretes TGF-β2 that improves metabolic health.
About The Cover
ONLINE COVER Imaging Contractions. Monitoring uterine contractions is critical for reducing the risk of complications during labor, but current methods are invasive and lack spatial and temporal precision. Wu et al. have developed an imaging technique called electromyometrial imaging (EMMI) that can noninvasively generate high-resolution, three-dimensional (3D) electrical potential maps during uterine contractions. EMMI enabled visualization of the initiation and propagation of uterine contractions with high resolution in pregnant sheep. The image shows the uterine myometrial electrical signals in the background with a superimposed 3D reconstruction of the sheep uterus during contractions in the foreground (red and blue represent areas of greatest contraction). [CREDIT: WU ET AL./SCIENCE TRANSLATIONAL MEDICINE]