Contents
13 September 2017
Vol 9, Issue 407
Vol 9, Issue 407
Research Articles
- Endothelial APLNR regulates tissue fatty acid uptake and is essential for apelin’s glucose-lowering effects
Inhibition of FABP4 rescues defective apelin signaling, decreases fatty acid accumulation, and promotes insulin sensitivity.
- Tumor lymphangiogenesis promotes T cell infiltration and potentiates immunotherapy in melanoma
Tumor lymphangiogenesis, a driver of immunosuppression and metastasis, also potentiates immunotherapy.
- Targeted inhibition of Gq signaling induces airway relaxation in mouse models of asthma
Local pharmacological inhibition of Gq results in airway relaxation in mouse models of asthma.
- Peptide probes detect misfolded transthyretin oligomers in plasma of hereditary amyloidosis patients
Peptide probes detect misfolded transthyretin oligomers in amyloidosis patient plasma.
Editors' Choice
- Do not cross to avoid an exacerbation
Reducing IgE with Omalizumab in children with asthma improves the plasmacytoid dendritic cell interferon response to virus in vitro.
- In the mood for food
A neuronal subpopulation in the central amygdala promotes food consumption.
- Problems with mast transit
Mast cell inhibition prevents heterotopic ossification in a model of fibrodysplasia ossificans progressiva.
- NLRP3, keep it down so we can hear
A gain-of-function mutation in NLRP3 is associated with cochlear inflammation and hearing loss.
- Fat chance for creatine deficiency
Creatine metabolism in adipose tissue is necessary to burn off extra dietary calories and helps prevent obesity.
About The Cover
ONLINE COVER Just Apelin-g Around. Apelin is a naturally occurring peptide which blocks the uptake of fatty acids from the blood and thereby slows the development of conditions such as diabetes and atherosclerosis. This image shows the distribution of apelin (green) in the white adipose tissue, demonstrating its localization in endothelial cells (red), while cell nuclei are highlighted in blue. Hwangbo et al. investigated the mechanism of action of apelin and discovered a drug that can mimic its function and thereby promote metabolic health in a mouse model. [CREDIT: B. SHARMA/YALE SCHOOL OF MEDICINE]