Contents
19 July 2017
Vol 9, Issue 399
Vol 9, Issue 399
Research Articles
- A multidirectional gravity-assist algorithm that enhances locomotor control in patients with stroke or spinal cord injury
A robotic harness optimizing gravity-dependent gait interactions enables natural locomotion across activities of daily living in people with spinal cord injury or stroke.
- The microvascular niche instructs T cells in large vessel vasculitis via the VEGF-Jagged1-Notch pathway
Microvascular endothelial cells in the arterial adventitia have immunoregulatory function and build an instructive tissue niche for the induction of pathogenic T cells in giant cell arteritis.
- A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma
A trial of autologous T cells redirected to a specific mutation in glioblastoma patients illustrates mechanisms of resistance.
- In situ expansion of engineered human liver tissue in a mouse model of chronic liver disease
An engineered microenvironment supports expansion of adult human engineered liver tissue after implantation in a mouse model of liver injury.
Editors' Choice
- Tailor-made T cells for cancer therapy
Investigators from two teams have created personalized vaccines for the treatment of melanoma by identifying tumor-specific neoantigens.
- Counting on carbon quantum dots to clear infection
Carbon quantum dots safely treat corneal bacterial infection using their membrane-disrupting positive charge.
- The riddle of CHD8 haploinsufficiency in autism spectrum disorder
Leading autism-associated mutation in mouse partially mimics human disorder.
Erratum
About The Cover
ONLINE COVER Making Strides in Neurorehabilitation. This stick diagram represents a patient with spinal cord injury walking over irregularly-spaced rungs of a ladder (orange) without crutches. Mignardot et al. developed an algorithm that personalizes rehabilitation support by adjusting the forward and upward forces a robotic harness provides to the torso of patients recovering from stroke or spinal cord injury. After 1 hour of overground training using the gravity-assist approach, patients showed immediate improvements in harness-free locomotion. Larger clinical trials will help determine whether gravity-assistive support during neurorehabilitation enhances long-term recovery. [CREDIT: MIGNARDOT ET AL./SCIENCE TRANSLATIONAL MEDICINE]