Contents
23 May 2018
Vol 10, Issue 442
Vol 10, Issue 442
Perspective
- Cancer metabolism gets physical
The physical microenvironment regulates cancer cell metabolism, and engineered culture systems need to reflect physical properties of tumors.
Research Articles
- Striatal dopamine regulates systemic glucose metabolism in humans and mice
Modulation of the striatal dopamine system affects glucose metabolism in humans and mice.
- A rationally designed NRP1-independent superagonist SEMA3A mutant is an effective anticancer agent
An NRP1-independent, non-natural SEMA3A mutant isoform is a parenterally deliverable anticancer drug that normalizes the vasculature.
- Derepression of co-silenced tumor suppressor genes by nanoparticle-loaded circular ssDNA reduces tumor malignancy
Circular ssDNA can sequester inhibitory microRNAs to restore tumor suppressor gene function, thereby inhibiting tumor progression.
- Adult rat myelin enhances axonal outgrowth from neural stem cells
Axons emerging from rat neural stem cell implants in the injured spinal cord of rat recipients are stimulated to grow by myelin.
Editors' Choice
- Opening the eyes on autism
Nine- to 10-month-old infants who develop autism show early enhanced pupillary light reflex compared with infants who did not develop autism.
- Blocking IL-6 signaling deflates pulmonary arterial hypertension
IL-6 signaling contributes to the pathogenesis of pulmonary arterial hypertension by orchestrating pulmonary arterial smooth muscle cell expansion.
- A fatty link between heart disease and autoimmunity
Atherogenic hyperlipidemia drives IL-27 production by dendritic cells to support follicular T cell differentiation and systemic autoimmune disorders in mice.
About The Cover
ONLINE COVER Stimulating Glucose Control. This image depicts deep brain stimulation (DBS), a method used to deliver electrical stimuli to specific brain areas. Ter Horst et al. showed that DBS applied to the striatal area of the brain promoted dopamine release that in turn increased hepatic and peripheral insulin sensitivity in patients with type 2 diabetes. Conversely, pharmacological dopamine depletion reduced systemic insulin sensitivity in healthy subjects. The findings highlight an underappreciated link between brain dopamine and systemic glucose metabolism and suggest that modulation of brain dopamine could be a potential strategy for treating diabetes.
[CREDIT: PASIEKA/SCIENCE PHOTO LIBRARY/GETTY IMAGES]