Contents
17 October 2018
Vol 10, Issue 463
Vol 10, Issue 463
Focus
- Health and societal implications of medical and technological advances
Scientific and technological breakthroughs are transforming the future of medicine and health, but they inevitably carry risks and have societal implications that need to be addressed proactively.
Research Articles
- A dysbiotic microbiome triggers TH17 cells to mediate oral mucosal immunopathology in mice and humans
Combined patient and animal model studies implicate microbiota-triggered TH17 cells as disease drivers and therapeutic targets in periodontitis.
- In utero priming of highly functional effector T cell responses to human malaria
Fetal malaria-responsive effector CD4+ T cells provide protection from childhood malaria in infants born to mothers with placental malaria.
- Avidity-based binding to HER2 results in selective killing of HER2-overexpressing cells by anti-HER2/CD3
T cell–dependent bispecific antibodies with bivalent low affinity binding to HER2 are more selective for tumor cells that overexpress the target.
Research Resource
- Mixed-effects association of single cells identifies an expanded effector CD4+ T cell subset in rheumatoid arthritis
Mixed-effects regression of single-cell data accounts for confounding variation and reveals an expanded CD4+ T cell population in rheumatoid arthritis.
Editors' Choice
- Self-defeating CAR-Ts protect leukemic cells
Transfer of a CAR gene to a leukemic cell confers resistance to CAR-T cell therapy.
- Harnessing the immune response to improve functional healing
Interleukin-4–conjugated gold nanoparticles promote M2 macrophage polarization and functional muscle recovery in an ischemic mouse model.
- Sustained obesity starts in early childhood
Accelerated weight gain during early childhood predicts sustained obesity.
Erratum
About The Cover
ONLINE COVER Smile! Oral health can be taken for granted, but many people are afflicted by periodontitis, an inflammatory disease that can lead to jaw bone loss. Dutzan et al. studied samples from humans and a mouse model of periodontitis to understand disease development. They discovered that T helper 17 (TH17) cells driven by the microbiome were pathogenic, and targeting these cells relieved periodontitis symptoms in mice. People naturally deficient in TH17 cells were less likely to develop periodontitis. As TH17-targeting small molecules are being developed clinically, these results could lead to a therapy that gives periodontitis patients something to smile about. [CREDIT: ZOLJO/ISTOCK.COM]