Contents
20 September 2017
Vol 9, Issue 408
Vol 9, Issue 408
Focus
- Single-cell analyses to tailor treatments
Single-cell RNA-seq could play a key role in personalized medicine by facilitating characterization of cells, pathways, and genes associated with human diseases such as cancer.
Research Articles
- Responsive monitoring of mitochondrial redox states in heart muscle predicts impending cardiac arrest
Monitoring of mitochondrial redox states of the epicardium predicts impending myocardial dysfunction and cardiac arrest.
- Cancer immunotherapy with recombinant poliovirus induces IFN-dominant activation of dendritic cells and tumor antigen–specific CTLs
PVSRIPO infection of tumors elicits antitumor immunity by damaging neoplastic cells and activating type I IFN responses in antigen-presenting cells.
- Protection against a mixed SHIV challenge by a broadly neutralizing antibody cocktail
A combination of HIV-1–specific broadly neutralizing antibodies is necessary to protect rhesus monkeys against a mixed SHIV challenge.
- Neutrophil transfer of miR-223 to lung epithelial cells dampens acute lung injury in mice
Intercellular transfer of miR-223 from neutrophils to alveolar epithelial cells reduces lung inflammation in a mouse model of ventilator-induced lung injury or pulmonary bacterial infection.
- Combined OX40L and mTOR blockade controls effector T cell activation while preserving Treg reconstitution after transplant
OX40L blockade synergizes with sirolimus to prevent GVHD by controlling effector T cell activation while supporting Treg reconstitution.
Editors' Choice
- Cerebral ischemia comes in waves
Subarachnoid blood induces spreading depolarizations, which are associated with cortical infractions.
- Education isn’t everything (for infant immunity)
A deficit in tissue-resident memory T cell production helps explain virus susceptibility in early life.
- Blocking cell death to enhance cell death
Inhibiting caspase activation during apoptosis may enhance the ability of the immune system to target cancer cells.
- Learning from cancer to promote weight loss
Growth differentiation factor 15 suppresses appetite and promotes weight loss by activating a receptor expressed in two brain regions.
About The Cover
ONLINE COVER Mitochondria in the Spotlight. Within a mitochondrion (pictured), the electron transport chain produces energy for a cell. Perry et al. developed an imaging system using resonance Raman spectroscopy to quantify the mitochondrial redox state in real-time. By shining a laser on the heart surface, the authors could detect and quantify changes in mitochondrial redox state during restricted oxygen delivery and predict imminent cardiac arrest in rats. This imaging system could be useful for monitoring tissue oxygenation during surgery. [CREDIT: SCIENCE PICTURE CO./SCIENCE SOURCE]