Contents
20 February 2019
Vol 11, Issue 480
Vol 11, Issue 480
Focus
- Challenges for mesenchymal stromal cell therapies
Clinical trials of mesenchymal stromal cell therapies reveal a challenging heterogeneous landscape, including diverse therapeutic targets, patient categories, cell sources, and potential mechanisms of action.
Research Articles
- The nonlesional skin surface distinguishes atopic dermatitis with food allergy as a unique endotype
Patients with atopic dermatitis and food allergy have an immature epithelial barrier and type 2 immune activation in their skin.
- Sodium chloride is an ionic checkpoint for human TH2 cells and shapes the atopic skin microenvironment
Sodium chloride induces and amplifies human TH2 cell responses, potentially shaping the atopic skin microenvironment.
- Brain metabolism modulates neuronal excitability in a mouse model of pyruvate dehydrogenase deficiency
Decreased metabolic flux due to deficient mitochondrial pyruvate dehydrogenase causes excitability dysfunction that can be modulated by acetate.
- Estimating cholera incidence with cross-sectional serology
Cross-sectional Vibrio cholerae–related antibody measures can be used to estimate cholera incidence in a population.
Editors' Choice
- Immunity to CRISPR-Cas9
Evaluation of patient serum samples commonly reveals preexisting anti-Cas9 antibodies and T cells.
- Anxious to lose weight
Anxiety leads to increased whole-body energy expenditure and thermogenesis in mice, preventing weight gain upon high-fat diet feeding.
- Don’t overlook the lung
The local lung microbiota provoke inflammation associated with lung adenocarcinoma by activating lung-resident γδ T cells in mice.
Erratum
About The Cover
ONLINE COVER More Than Skin Deep. Noninvasive skin tape stripping of healthy-looking skin (pictured) is being used to elucidate the biological underpinnings of food allergy in children with atopic dermatitis (Leung et al.). In this study, half of a cohort of children with atopic dermatitis, a condition characterized by itchy red patches of skin, also suffered from food allergy. The investigators found striking differences among nonlesional atopic dermatitis skin samples depending on food allergy status. Even normal-appearing skin in children with atopic dermatitis and food allergy may harbor a defective epithelial barrier, possibly allowing the entry of and sensitization to food allergens. [CREDIT: VOLODYMYRV/ISTOCKPHOTO]