Contents
28 June 2017
Vol 9, Issue 396
Vol 9, Issue 396
Research Articles
- Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses
Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses in vitro and in vivo.
- Linker proteins restore basement membrane and correct LAMA2-related muscular dystrophy in mice
Transgenic expression of two small linker proteins restores muscle function and prolongs life span in a mouse model of LAMA2-related muscular dystrophy.
- Type 2 immunity is protective in metabolic disease but exacerbates NAFLD collaboratively with TGF-β
Development of NASH fibrosis is accompanied by accumulation of hepatic eosinophils and driven by TGF-β and profibrotic type 2 inflammation.
Report
- Genetic and epigenetic inactivation of SESTRIN1 controls mTORC1 and response to EZH2 inhibition in follicular lymphoma
SESTRIN1 is a tumor suppressor deleted or epigenetically silenced by mutated EZH2.
Editors' Choice
- Fortifying the BBB: Border control by increasing regulators
Treatment with exogenous regulatory T cells fortifies the blood-brain barrier after tissue plasminogen activator therapy in models of acute ischemic stroke.
- Surf’s up for ER stress
A new type of biological clock regulates the unfolded protein response.
- Epigenetics make transient states of cancer therapy resistance permanent
Resistance to targeted cancer therapies is mediated by stabilization of transient insensitive states.
- Strengthening brittle bones
Decreased WNT1 signaling weakens bones but is partially reversed by blocking the WNT1 inhibitory regulator sclerostin.
About The Cover
ONLINE COVER Bat-tling Zoonotic Infections. Coronaviruses are endemic in multiple mammalian species, including bats, and can jump into the naïve human population at anytime. Sheahan et al. identified an antiviral drug that had activity against coronaviruses from various hosts. Their findings indicate this drug could be useful during the next zoonotic coronavirus outbreak. [CREDIT: BLICKWINKEL/ALAMY STOCK PHOTO]