Contents
20 March 2019
Vol 11, Issue 484
Vol 11, Issue 484
Research Articles
- A cytochrome P450 allele confers pyrethroid resistance on a major African malaria vector, reducing insecticide-treated bednet efficacy
A cytochrome P450 DNA marker in a major mosquito vector of malaria indicates that pyrethroid resistance reduces bednet efficacy.
- Intrinsic cell-penetrating activity propels Omomyc from proof of concept to viable anti-MYC therapy
We demonstrate the pharmacologic potential of the purified cell-penetrating Omomyc mini-protein to directly inhibit MYC function in vitro and in vivo.
- Amphiphysin 2 modulation rescues myotubular myopathy and prevents focal adhesion defects in mice
Modulation of human amphiphysin 2 expression by genetic cross and viral delivery rescues all hallmarks of X-linked centronuclear myopathy in mice.
- Delta-like protein 3 expression and therapeutic targeting in neuroendocrine prostate cancer
DLL3 is overexpressed in neuroendocrine prostate cancer and is a potential therapeutic target.
Focus
- Advances in artificial pancreas systems
The artificial pancreas for managing type 1 diabetes has progressed from research into clinical practice, revealing areas for future advancements.
Editors' Choice
- And the beat goes on
A flexible, conductive, 3D-printed patch restores conduction after cardiac injury in a canine model.
- Upsetting the excitatory-inhibitory balance hypothesis of autism
Increased excitatory-inhibitory ratio of neuronal activity may be protective rather than pathological in mouse model of autism.
- SAMpling cancer development one carbon at a time
PKCλ/ι depletion promotes metabolic reprogramming during neuroendocrine prostate cancer differentiation by increasing DNA methylation.
About The Cover
ONLINE COVER Beating Back the Bloodsuckers. The female mosquito vector of malaria (pictured) takes a blood meal at night, a key step in the parasite's life cycle that can be prevented using insecticide-treated bednets. Unfortunately, insecticide resistance among mosquito malaria vectors in Africa is rapidly increasing. A DNA marker identified in the gene encoding cytochrome P450, an enzyme that breaks down the insecticides used for treating bednets, enabled Weedall et al. to track the emergence of insecticide resistance in mosquitoes in Africa. A field hut study in Cameroon confirmed that mosquitoes carrying this resistance marker were better able to survive taking a blood meal from human volunteers sleeping under insecticide-treated bednets. [CREDIT: ALEX WILD]