Contents

12 September 2018
Vol 10, Issue 458

About The Cover

Cover image expansion

ONLINE COVER The Iron in the Fire of Hematopoiesis. This image shows molten iron, representing the focus of a study by Kao et al., where the authors linked the role of iron metabolism to unexpected benefits of a drug that bolsters platelets. Eltrombopag was designed as a thrombopoietin receptor agonist to stimulate platelet recovery for patients with thrombocytopenia, but clinical experience has shown that it also stimulates hematopoietic stem cell function in general, prompting a search for the underlying mechanism. The authors determined that in addition to its effects on the thrombopoietin receptor, eltrombopag chelates intracellular iron in hematopoietic stem cells, thus stimulating their activity. [CREDIT: THOMAS KOEHLER/PHOTOTHEK VIA GETTY IMAGES]