Contents
14 November 2018
Vol 10, Issue 467
Vol 10, Issue 467
Editorial
- Patents and drug insurance: Clash of the Titans?
The confluence of patent law and drug insurance creates a unique challenge for patients in the United States and could affect future biomedical R&D.
Research Articles
- Cell and fluid sampling microneedle patches for monitoring skin-resident immunity
A minimally invasive microneedle device allows repeated sampling of tissue-resident immune cell populations from the skin.
- Transcellular stomach absorption of a derivatized glucagon-like peptide-1 receptor agonist
An orally delivered GLP-1 analog coformulated with the absorption enhancer SNAC achieves transcellular-directed absorption in the stomach.
- Sodium-glucose transporter 2 is a diagnostic and therapeutic target for early-stage lung adenocarcinoma
Lung premalignancy and early-stage adenocarcinoma use a mechanism of glucose transport that can be targeted for early diagnosis and treatment.
- Commensal bacteria contribute to insulin resistance in aging by activating innate B1a cells
The increase of insulin resistance in “healthy” aging can be explained by a gut microbiota–monocyte–B1a B cell axis.
Editors' Choice
- Illuminating Aurora dependencies
RB1 loss of function in small cell lung cancer causes dependency on Aurora kinases for survival, which can be targeted therapeutically.
- Exosomal microRNA: The revolutionary endogenous Innerspace nanotechnology
T lymphocytes release exosomes containing specific microRNAs that cause apoptosis of pancreatic β cells in type 1 diabetes.
- Charting the course of metastatic cells
An implantable biomaterial recruits rare tumor cells and enables long-term observation of microenvironmental evolution.
Erratum
About The Cover
ONLINE COVER "Peak"-ing into Tissue Immune Responses. Blood sampling is a common method to assess a patient's immune status, but may not capture crucial immune reactions that occur in tissues. To examine tissue immunity, Mandal et al. designed a microneedle device, shown here with scanning electron microscopy, to assess cells within the skin. These microneedles can sample antigen-specific T cells and other cells in mouse and human skin, revealing immune responses not detectable in the peripheral circulation. The microneedles can be used repeatedly to assess immune responses over time and could lead to a better understanding of tissue-resident immunity. [CREDIT: MANDAL ET AL./SCIENCE TRANSLATIONAL MEDICINE]