Contents
19 September 2018
Vol 10, Issue 459
Vol 10, Issue 459
Review
- The hallmarks of successful anticancer immunotherapy
Various features of the tumor and immune system influence the success of immunotherapy.
Research Articles
- Arginine deficiency is involved in thrombocytopenia and immunosuppression in severe fever with thrombocytopenia syndrome
Arginine deficiency is involved in thrombocytopenia and immunosuppression in severe fever with thrombocytopenia syndrome.
- The PTH/PTHrP-SIK3 pathway affects skeletogenesis through altered mTOR signaling
Disrupting the PTH/PTHrP-SIK3 pathway impairs degradation of DEPTOR, affects mTOR signaling, and leads to abnormalities in skeletal development.
- Axonal organization defects in the hippocampus of adult conditional BACE1 knockout mice
Conditional loss of BACE1 in adult mouse brain results in abnormalities in the hippocampal mossy fiber pathway, which is important for learning and memory.
- Repurposing ciclopirox as a pharmacological chaperone in a model of congenital erythropoietic porphyria
The off-patent marketed antifungal ciclopirox improves symptoms in a mouse model of congenital erythropoietic porphyria.
Editors' Choice
- Identifying and targeting residual leukemic cells
Targeting leukemia regenerating cells following chemotherapy can prevent relapse of the disease.
- Stroke prevention: Learning from the master (and COMMANDER)
Adding rivaroxaban to standard therapy in patients with heart failure and no atrial fibrillation did not show any beneficial effect on death risk.
- Send in the decoys: Cell-like particles ameliorate inflammatory autoimmune arthritis
Neutrophil membrane–coated nanoparticles reduce symptoms of rheumatoid arthritis in mice.
About The Cover
ONLINE COVER Manipulating Metabolism. Shown here are crystals of the amino acid arginine, important for cellular metabolism. Li et al. discovered that arginine metabolism is disrupted in patients infected with severe fever with thrombocytopenia syndrome (SFTS) virus. This recently identified bunyavirus causes potentially fatal thrombocytopenia. The investigators then performed a randomized controlled clinical trial administering arginine to patients with SFTS, which led to reduced platelet activation and faster viral clearance. Their results not only shed light on pathogenesis of a fatal infection, but also could help pave the way for a targeted treatment. [CREDIT: DAVID PARKER/SCIENCE SOURCE]